Overview
Celemics’ CancerScreen Panel is designed to detect all types
of variants including gene rearrangement in various somatic
cancer-related genes.
(Core, 50, 100, and 400). Customers can choose a target enrichment panel that
best suits their research or diagnostic needs. Also, if the gene of interest does not exist in the panel, it can be added
separately through our gene add-on service.
Features &
Benefits
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- Optimized panel for solid cancer
- Assess DNA, RNA, and the whole CDS regions (RefSeq) of up to 407 genes
and rearrangement regions associated with solid cancer
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- High sensitivity and specificity
- Detect low-frequency and rare variants with high sequencing depths
- Capture the GC rich and homologous regions with Celemics
Proprietary probe design technology
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- Cost-effective sequencing
- Lower sequencing costs compared to competitor product due to
Celemics’ superior uniformity of coverage - Provides flexible panels that are gene add-on capable
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- Assess all variant types
- Detect all mutation types including SNV, Indel, Large Indel, CNV,
Rearrangement, MSI, and TMB in a single assay
Performance
Performance Comparison with Competitor Product Comparison data with competitors' products
Higher on-target ratio, uniformity, coverage at 100X compared to competitor product over the target regions including exons and introns
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Performance Comparison over GC-rich Regions
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More uniform read depths over GC-rich regions compared to competitor products
Flexible
panel options
CancerScreen Panel - Core
| ALK | APC | BRAF | EGFR | ERBB2 | KRAS | MET | NRAS | PIK3CA | RET | ROS1 | SMAD4 | TP53 |
Genes in bold indicate fusion analysis
CancerScreen Panel - 50
| ABL1 | AKT1 | ALK | APC | ATM | BRAF | BRCA1 | BRCA2 | CDH1 | CDK4 | CDK6 | CDKN2A |
| CSF1R | CTNNB1 | DDR2 | EGFR | ERBB2 | ERBB4 | ESR1 | FGFR1 | FGFR2 | FGFR3 | GNA11 | GNAQ |
| GNAS | HRAS | IDH1 | IDH2 | JAK2 | KDR | KIT | KRAS | MAP2K1 | MET | MLH1 | MTOR |
| MYC | MYCN | NOTCH1 | NRAS | NTRK1 | PDGFRA | PIK3CA | PTCH1 | PTEN | PTPN11 | RB1 | RET |
| ROS1 | SMAD4 | SMO | SRC | STK11 | TP53 |
Genes in bold indicate fusion analysis
CancerScreen Panel - 100
| ABL1 | AKT1 | AKT2 | AKT3 | ALK | APC | ARID1A | ARID1B | ARID2 | ATM | ATRX | AURKA |
| AURKB | BARD1 | BCL2 | BLM | BMPR1A | BRAF | BRCA1 | BRCA2 | BRIP1 | CDH1 | CDK4 | CDK6 |
| CDKN2A | CHEK2 | CSF1R | CTNNB1 | DDR2 | EGFR | EPCAM | EPHB4 | ERBB2 | ERBB3 | ERBB4 | EZH2 |
| FBXW7 | FGFR1 | FGFR2 | FGFR3 | FLT3 | GNA11 | GNAQ | GNAS | HNF1A | HRAS | IDH1 | IDH2 |
| IGF1R | ITK | JAK1 | JAK2 | JAK3 | KDR | KIT | KRAS | MDM2 | MET | MLH1 | MPL |
| MRE11 | MSH2 | MSH6 | MTOR | MUTYH | NBN | NF1 | NOTCH1 | NPM1 | NRAS | NTRK1 | PALB2 |
| PDGFRA | PDGFRB | PIK3CA | PIK3R1 | PMS2 | PRSS1 | PTCH1 | PTCH2 | PTEN | PTPN11 | RAD50 | RAD51C |
| RAD51D | RB1 | RET | ROS1 | SLX4 | SMAD4 | SMARCB1 | SMO | SRC | STK11 | SYK | TERT |
| TOP1 | TP53 | VHL |
CancerScreen Panel - 400
| ABL1 | ABL2 | ADGRA2 | AKT1 | AKT2 | AKT3 | ALK | AMER1 | APC | APCDD1 | APEX1 | APOB |
| APOBEC1 | AR | ARAF | ARFRP1 | ARID1A | ARID1B | ARID2 | ASXL1 | ATM | ATP11B | ATR | ATRX |
| AURKA | AURKB | AXIN1 | AXL | B2M | B3GAT1 | BACH1 | BAP1 | BARD1 | BCL2 | BCL6 | BCL9 |
| BCOR | BCR | BIRC2 | BIRC3 | BLM | BRAF | BRCA1 | BRCA2 | BRD2 | BRD3 | BRD4 | BRIP1 |
| BTG1 | BTK | BTLA | CARD11 | CASP5 | CASP8 | CBFB | CBL | CDK12 | CDK4 | CDK6 | CDK8 |
| CDKN1A | CDKN1B | CDKN2A | CDKN2B | CDKN2C | CDX2 | CEBPA | CHD1 | CHD2 | CHD4 | CHEK1 | CHEK2 |
| CHUK | CIC | CRBN | CREBBP | CRKL | CRLF2 | CSF1R | CSF2 | CSF2RA | CSF2RB | CSNK2A1 | CTCF |
| CTLA4 | CTNNA1 | CTNNB1 | CUL3 | CUL4A | CUL4B | CXCL10 | CXCL11 | CXCL9 | CXCR3 | CYLD | CYP17A1 |
| DAXX | DCUN1D1 | DDR2 | DICER1 | DIS3 | DNMT1 | DNMT3A | DOCK2 | DOT1L | EGFR | ELMO1 | EML4 |
| EMSY | EP300 | EPHA3 | EPHA5 | EPHA6 | EPHA7 | EPHB1 | EPHB4 | EPHB6 | ERBB2 | ERBB3 | ERBB4 |
| ERCC1 | ERCC2 | ERG | ERRFI1 | ESR1 | ETV1 | ETV4 | ETV5 | ETV6 | EWSR1 | EYA2 | EZH2 |
| FANCA | FANCC | FANCD2 | FANCE | FANCF | FANCG | FANCI | FANCL | FANCM | FAS | FAT1 | FAT3 |
| FBXW7 | FGF1 | FGF10 | FGF12 | FGF14 | FGF19 | FGF2 | FGF23 | FGF3 | FGF4 | FGF6 | FGF7 |
| FGFR1 | FGFR2 | FGFR3 | FGFR4 | FH | FLCN | FLT1 | FLT3 | FLT4 | FOXA1 | FOXL2 | FOXO3 |
| FOXP3 | FRS2 | FUBP1 | GABRA6 | GAS6 | GATA1 | GATA2 | GATA3 | GATA4 | GATA6 | GID4 | GLI1 |
| GNA11 | GNA13 | GNAQ | GNAS | GRIN2A | GRM3 | GSK3B | GUCY1A2 | GZMA | GZMB | GZMH | H3F3A |
| HGF | HIST1H3B | HNF1A | HOXA3 | HRAS | HSD3B1 | HSP90AA1 | IDH1 | IDH2 | IDO1 | IDO2 | IFITM1 |
| IFITM3 | IFNA1 | IFNB1 | IFNG | IGF1 | IGF1R | IGF2 | IGF2R | IKBKE | IKZF1 | IL12A | IL12B |
| IL2 | IL23A | IL6 | IL7R | INHBA | INPP4B | INSR | IRF2 | IRF4 | IRS2 | ITGAE | ITK |
| JAK1 | JAK2 | JAK3 | JUN | KAT6A | KDM5A | KDM5C | KDM6A | KDR | KEAP1 | KEL | KIT |
| KLF4 | KLHL6 | KMT2A | KMT2B | KMT2C | KNSTRN | KRAS | LAG3 | LMO1 | LRP1B | LRP6 | LTK |
| LYN | LZTR1 | MAGI2 | MAGOH | MAML1 | MAP2K1 | MAP2K2 | MAP2K4 | MAP3K1 | MAP3K13 | MAPK1 | MAX |
| MCL1 | MDM2 | MDM4 | MED12 | MEF2B | MEN1 | MET | MITF | MLH1 | MPL | MRE11 | MSH2 |
| MSH6 | MTOR | MUTYH | MYB | MYC | MYCL | MYCN | MYD88 | MYO18A | NCOA3 | NCOR1 | NF1 |
| NF2 | NFE2L2 | NFKBIA | NOTCH1 | NOTCH2 | NOTCH3 | NOTCH4 | NPM1 | NRAS | NSD1 | NSD3 | NTRK1 |
| NTRK2 | NTRK3 | NUP93 | NUTM1 | PAK3 | PAK5 | PALB2 | PARP1 | PARP2 | PARP3 | PARP4 | PAX5 |
| PBRM1 | PDCD1 | PDCD1LG2 | PDGFRA | PDGFRB | PDK1 | PGR | PHF6 | PHLPP2 | PIK3C2B | PIK3C3 | PIK3CA |
| PIK3CB | PIK3CG | PIK3R2 | PKHD1 | PLCG1 | PLCG2 | PMS2 | PNP | PNRC1 | POLD1 | POLE | PPARG |
| PPP2R1A | PRDM1 | PREX2 | PRF1 | PRKAR1A | PRKCI | PRKDC | PRPF40B | PRSS8 | PTCH1 | PTCH2 | PTEN |
| PTK2 | PTPN11 | PTPRC | PTPRD | QKI | RAB35 | RAC1 | RAC2 | RAD17 | RAD50 | RAD51 | RAD52 |
| RAD54L | RAF1 | RANBP2 | RARA | RB1 | RBM10 | REL | RET | RHEB | RHOA | RHOB | RICTOR |
| ROBO1 | ROBO2 | ROS1 | RPA1 | RPS6KB1 | RPTOR | RUNX1 | RUNX1T1 | RUNX3 | SDHA | SDHB | SDHC |
| SDHD | SEMA3A | SEMA3E | SET | SETBP1 | SETD2 | SF3A1 | SF3B1 | SH2B3 | SKP2 | SLIT2 | SMAD2 |
| SMAD3 | SMAD4 | SRSF2 | SRSF7 | STAG2 | STAT3 | STAT4 | TERT | TET2 |
Applications
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Somatic cancer related fields