PharmacoScreen Panel

Flexible choice targeting over 120 genes associated with Pharmacogenomics
Available with prescribed drugs of the corresponding diseases

Overview

For Drug Prescription and Drug Metabolism

The main target of PharmacoScreen panel is the genes associated with prescribed drugs of the corresponding diseases.
Celemics has prepared three types of panels (Standard, Epilepsy, and Anti-Tuberculosis) to allow for client-specific selection.

 

1. Standard
The PharmacoScreen Standard panel is designed to research organ transplant-related genes through assessment of drug metabolism, transporters, and Parkinson’s disease-related genes.

 

2. Epilepsy
The PharmacoScreen Epilepsy panel is designed for genetic researches related to anti-epileptic drugs. Our panel is also useful for assessing an individual’s genetic characteristics to accurately prescribe relevant drugs.

 

3. Anti-tuberculosis
The main target of the PharmacoScreen Anti-tuberculosis panel is the genes associated with a drug-induced liver injury which is an important factor for drug development as well as precise drug prescription

Pharmacoscreen image
Features & Benefits

Assess Extensive Target Regions Associated with Pharmacogenomics

Celemics’ PharmacoScreen panel was developed in collaboration with 4 major University hospitals; designed to target over 120 genes associated with Pharmacokinetics and Pharmacodynamics. The designed panels have been validated with actual clinical specimen for proven clinical usage.

Flexible Panel Contents

Each of PharmacoScreen Staandard, PharmacoScreen Epilepsy, PharmacoScreen Anti-tuberculosis contain 122, 91, and 132 genes, respectively. However, these panel are not limited to current set of genes; Celemics offers flexibility in modifying the panel contents by our gene add-on service, allowing customers to expand target region of interest.

Specification

*Gene Add-On Service: Genes can be added by customer’s request.
Standard Epilepsy Anti-tuberculosis
Gene count* 283 genes 91 genes 132 genes
Covered region Whole CDS + UTR (-50 bp, +10 bp)
Target size 634 kb 575 kb 186 kb
Mutation type SNV, Indel, CNV
Sample type (amount) Blood (> 50 ng of fragmented DNA)
Platform All sequencers from Illumina, Thermo Fisher, MGI, and PacBio
Bioinformatics pipeline Primary, Secondary and Tertiary analysis result (FASTQ to VCF, VCF to Clinical report)

Specification - Gene List

Pharmaco
Screen Panel
Standard
ABCA1 ABCB1 ABCB11 ABCB4 ABCB7 ABCC1 ABCC2 ABCC3 ABCC4 ABCC5 ABCC6 ABCC8 ABCC9 ABCG1
ABCG2 ABP1 ACE ADH1A ADH1B ADH1C ADH4 ADH5 ADH6 ADH7 ADRB1 ADRB2 AHR AKAP9
ALB ALDH1A1 ALDH2 ALDH3A1 ALDH3A2 ALOX5 AOX1 APOA1 APOA2 ARID5B ARNT ARSA ATP7A ATP7B
BDNF BRCA1 CA5P CACNA1C CBR1 CBR3 CDA CES1 CES2 CFTR CHST1 CHST10 CHST11 CHST13
CHST2 CHST3 CHST4 CHST5 CHST6 CHST7 CHST8 CHST9 COMT CPS1 CRHR1 CROT CYP11A1 CYP11B1
CYP11B2 CYP17A1 CYP19A1 CYP1A1 CYP1A2 CYP1B1 CYP20A1 CYP21A2 CYP24A1 CYP26A1 CYP26C1 CYP27A1 CYP27B1 CYP2A13
CYP2A6 CYP2A7 CYP2B6 CYP2B7P1 CYP2C18 CYP2C19 CYP2C8 CYP2C9 CYP2D6 CYP2E1 CYP2F1 CYP2J2 CYP2R1 CYP2S1
CYP39A1 CYP3A4 CYP3A43 CYP3A5 CYP3A7 CYP46A1 CYP4A11 CYP4B1 CYP4F11 CYP4F12 CYP4F2 CYP4F3 CYP4F8 CYP4Z1
CYP51A1 CYP7A1 CYP7B1 CYP8B1 DBH DCK DPYD DRD1 DRD2 EGFR EPHX1 EPHX2 ESR1 F5
FAAH FKBP5 FMO1 FMO2 FMO3 FMO4 FMO5 FMO6 G6PD GLCCI1 GRK4 GRK5 GSTA1 GSTA2
GSTA3 GSTA4 GSTA5 GSTM1 GSTM2 GSTM3 GSTM4 GSTM5 GSTO1 GSTP1 GSTT1 GSTT2 GSTZ1 HMGCR
HNMT HTR1A HTR2A KCNH2 KCNJ11 LDLR MAOA MAOB MAT1A METTL1 MTHFR NAT1 NAT2 NNMT
NQO1 NR1I2 NR1I3 NR3C1 NR3C2 NTRK2 ORM1 ORM2 P2RY1 P2RY12 PEAR1 PGAP3 PNMT PON1
PON2 PON3 POR PPARD PPARG PPP1R9A PRSS53 PTGIS PTGS1 PTGS2 QPRT RALBP1 RPL13 RXRA
RYR1 RYR2 SCN1A SCN2A SCN5A SERPINA7 SETD4 SLC10A1 SLC10A2 SLC13A1 SLC15A1 SLC15A2 SLC16A1 SLC19A1
SLC22A1 SLC22A11 SLC22A12 SLC22A13 SLC22A14 SLC22A2 SLC22A3 SLC22A4 SLC22A5 SLC22A6 SLC22A7 SLC22A8 SLC25A27 SLC28A1
SLC28A2 SLC28A3 SLC29A1 SLC29A2 SLC47A1 SLC47A2 SLC5A6 SLC6A3 SLC6A4 SLC6A6 SLC7A5 SLC7A7 SLC7A8 SLCO1A2
SLCO1B1 SLCO1B3 SLCO2B1 SLCO3A1 SLCO4A1 SLCO5A1 SOD2 SPG7 SPN SULT1A1 SULT1A2 SULT1A3 SULT1B1 SULT1C2
SULT1C4 SULT1E1 SULT2A1 SULT2B1 SULT4A1 TBXAS1 TPMT TPSG1 TYMS UGT1A UGT1A1 UGT1A10 UGT1A3 UGT1A4
UGT1A5 UGT1A6 UGT1A7 UGT1A8 UGT1A9 UGT2A1 UGT2B11 UGT2B15 UGT2B17 UGT2B28 UGT2B4 UGT2B7 UGT8 VDR
VKORC1 XDH ZNF423

 

Pharmaco
Screen Panel
Epilepsy
ANKK1 CACNA1A CACNA1B CACNA1D CACNA1E CACNA1F CACNA1G CACNA1H CACNA1I CACNA1S CACNA2D1 CACNA2D2 CACNA2D3 CACNA2D4
CACNB1 CACNB2 CACNB3 CACNB4 CACNG1 CACNG2 CACNG3 CACNG4 CACNG5 CACNG6 CACNG7 CACNG8 CDH13 CLCN2
EFHC1 GABRA1 GABRA2 GABRA3 GABRA4 GABRA5 GABRA6 GABRB1 GABRB2 GABRB3 GABRD GABRE GABRG1 GABRG2
GABRG3 GABRP GABRQ GABRR1 GABRR2 GABRR3 GRIA1 GRIA2 GRIA3 GRIA4 GRIK1 GRIK2 GRIK3 GRIK4
GRIK5 GRIN1 GRIN2A GRIN2B GRIN2C GRIN2D GRIN3A GRIN3B HNF4A HTR1B KCNA2 KCNB1 KCNC1 KCND3
KCNH1 KCNJ10 KCNQ2 KCNQ3 KCNT1 KCTD7 LEPR MAOA MAOB RBFOX1 SCN1A SCN2A SCN3A SCN8A
STS TPH1 TPH2 UGT1A10 UGT1A6 UGT1A7 UGT1A9              
Pharmaco
Screen Panel
Anti-
Tuberculosis
ABHD5 ADA ADORA2A ALAS1 ALPK2 ANO10 ASAH1 BACH1 BAX BCL2 BTLA CARD8 CASP1 CASP3
CASP8 CASP9 CAT CCL2 CD274 CD276 CD28 CD40 CD40LG CD80 CD86 CPA6 CTLA4 CYBA
DDX10 DPP4 ENTPD1 FAHD2A FAS FASLG FBXW8 FOXP3 GCLC GCLM GGT1 GPX1 GPX3 GPX4
GSR GSS GSTA1 GSTA2 GSTA3 GSTA4 GSTA5 GSTK1 GSTM2 GSTM3 GSTM4 GSTM5 GSTO1 GSTO2
GSTT2 GSTZ1 HAVCR2 HIF1A HMOX1 HMOX2 HSPA1L ICOS ICOSLG IDO1 IDO2 IFNG IFNGR1 IFNGR2
IL10 IL10RA IL12A IL12B IL12RB1 IL12RB2 IL17A IL17RA IL18 IL18R1 IL18RAP IL1A IL1B IL1R1
IL4 IL4R IL6 IL6R KCNE3 KCNIP3 KEAP1 KSR2 LAG3 LGALS9 MAFK MIR4272 MPO NFE2L2
NLRP3 NOS1 NOS2 NOS3 NT5E PDCD1 PDCD1LG2 PLXNA4 POLD3 PROM2 PSD3 SOD1 SOD3 SRXN1
STAT3 TGFB1 TGFBR1 THSD7B TNFRSF4 TNF TNFAIP3 TNFRSF14 TNFRSF1A TNFRSF1B TNFRSF9 TNFSF10 TNFSF14 TNFSF4
TNFSF9 TRIM43 TXNRD1 USP44 VTCN1 ZNF804B                

 

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Resources

Technical Resources

[Product Sheet] PharmacoScreen Panel

[Product Overview] Celemics Target Enrichment Panel Overview

[Catalogue] Celemics Products & Service Catalogue_All Products & Service

Safety Data Sheets

MSDS_PharmacoScreen Panel_Illumina_Enzymeplus

MSDS_PharmacoScreen Panel_Illumina

MSDS_PharmacoScreen Panel_Thermo Fisher

MSDS_PharmacoScreen Panel_MGI_EnzymePlus

MSDS_PharmacoScreen Panel_MGI